Final analysis of efficacy and safety of single-dose Ad26.COV2.S | New England Journal of Medicine | | |
Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial | The Lancet Child and Adolescent Health | | |
Efficacy, safety and tolerability of pyronaridine-artesunate in asymptomatic malaria-infected individuals: a randomized controlled trial | Clinical Infectious Diseases | | |
Neonatal rotavirus vaccine (RV3-BB) immunogenicity and safety in a neonatal and infant administration schedule in Malawi: a randomised, double-blind, four-arm parallel group dose-ranging study | The Lancet Infectious Diseases | | Rotavirus gastroenteritis |
A plain language summary of how well the single-dose Janssen vaccine works and how safe it is | | | |
Sequence and vector shapes vaccine induced antibody effector functions in HIV vaccine trials | | | |
Immunogenicity of alternative ten-valent pneumococcal conjugate vaccine schedules in infants in Ho Chi Minh City, Vietnam: results from a single-blind, parallel-group, open-label, randomised, controlled trial | The Lancet Infectious Diseases | | |
Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial | The Lancet Respiratory Medicine | | |
Effect of scheduled antimicrobial and nicotinamide treatment on linear growth in children in rural Tanzania: A factorial randomized, double-blind, placebo-controlled trial | | | |
Performance analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial cohort | Critical Care Explorations | | |
Immunogenicity and safety of a novel ten-valent pneumococcal conjugate vaccine in healthy infants in The Gambia: a phase 3, randomised, double-blind, non-inferiority trial | The Lancet Infectious Diseases | | |
Pyronaridine–artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study | | | |
Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma | PLoS Neglected Tropical Diseases | | |
Safety and efficacy of single-dose Ad26.COV2.S vaccine against COVID-19 | New England Journal of Medicine | | |
Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam | | | |
Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial | The Lancet Respiratory Medicine | | |
PREVAIL IV: A randomized, double-blind, two-phase, phase 2 trial of remdesivir versus placebo for reduction of Ebola virus RNA in the semen of male survivors | Clinical Infectious Diseases | | |
Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso | | | |
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Prevalence of Streptococcus pneumoniae in conjunctival flora and association with nasopharyngeal carriage among children in a Vietnamese community | | | |
Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries | | | |
Economic evaluation protocol of a short, all-oral bedaquiline-containing regimen for the treatment of rifampicin-resistant tuberculosis from the STREAM trial | | | |
Ebola-negative neonates born to Ebola-infected mothers after monoclonal antibody therapy: a case series | Lancet Child and Adolescent Health | | |
Challenges for drug repurposing in the COVID-19 pandemic era | Frontiers in Pharmacology | | |
DAR-901 vaccine for the prevention of infection with Mycobacterium tuberculosis among BCG-immunized adolescents in Tanzania: a randomized controlled, double-blind phase 2b trial | | | |
Remdesivir for the treatment of Covid-19 — final report | New England Journal of Medicine | | |
Effect of Enhanced Adherence Package on Early ART Uptake Among HIV-Positive Pregnant Women in Zambia: An Individual Randomized Controlled Trial | | | |
Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria | Pharmacogenetics and Genomics | | |
The Equatoguinean Malaria Vaccine Initiative: from the launching of a clinical research platform to malaria elimination planning in central West Africa | American Journal of Tropical Medicine and Hygiene | | |
Brief communication: immunogenicity of measles vaccine when co-administered with 10-valent pneumococcal conjugate vaccine | | | |
The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents | | | |
Respiratory syncytial virus vaccination during pregnancy and effects in infants | New England Journal of Medicine | | Respiratory syncytial virus |
Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial | The Lancet Infectious Diseases | | Rotavirus gastroenteritis |
Efficacy of a spatial repellent for control of malaria in Indonesia: a cluster-randomized controlled trial | American Journal of Tropical Medicine and Hygiene | | |
Serostatus cutoff levels and fold increase to define seroresponse to recombinant
vesicular stomatitis virus – Zaire Ebola virus envelope glycoprotein vaccine: An evidence-based analysis | | | |
Economic evaluation of short treatment for multidrug-resistant tuberculosis, Ethiopia and South Africa: the STREAM trial | Bulletin of the World Health Organization | | |
The China tuberculosis clinical trials consortium network: a model for international TB clinical trials capacity building | Infectious Diseases of Poverty | | |
Impact of the COVID-19 epidemic on a Pan-Asian academic oncology clinical trial | | | |
Effect of a chikungunya virus–like particle vaccine on safety and tolerability outcomes | | | |
A phase 1b randomized study of the safety and immunological responses to vaccination with H4:IC31, H56:IC31, and BCG revaccination in Mycobacterium tuberculosis-uninfected adolescents in Cape Town, South Africa | | | |
Pregnancy outcomes among women receiving rVSVΔ-ZEBOV-GP Ebola vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola | Emerging Infectious Diseases | | |
The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis | | | |
A Phase 2/3 double blinded, randomized, placebo-controlled study in healthy adult participants in Vietnam to examine the safety and immunogenicity of an inactivated whole virion, alum adjuvanted, A(H5N1) influenza vaccine (IVACFLU-A/H5N1) | | | |
Safety and immunogenicity of a novel 10-valent pneumococcal conjugate vaccine candidate in adults, toddlers, and infants in The Gambia-Results of a phase 1/2 randomized, double-blinded, controlled trial | | | |
A randomized, controlled trial of Ebola virus disease therapeutics | New England Journal of Medicine | | |
Cytomegalovirus infection is a risk factor for tuberculosis disease in infants | | | |
Efficacy and safety of sodium zirconium cyclosilicate in patients with baseline serum potassium level ≥ 5.5 mmol/L: pooled analysis from two phase 3 trials | | | |
Portable infrared imaging for longitudinal limb volume monitoring in patients with lymphatic filariasis | PLoS Neglected Tropical Diseases | | |
Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples | | | |
Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III-IV melanoma | Journal for the Immunotherapy of Cancer | | |
PREVAIL I cluster vaccination study with rVSVΔG-ZEBOV-GP as part of a public health response in Liberia | Journal of Infectious Diseases | | |
Immunogenicity and reactogenicity of ten-valent versus 13-valent pneumococcal conjugate vaccines among infants in Ho Chi Minh City, Vietnam: a randomised controlled trial | The Lancet Infectious Diseases | | |
A trial of a shorter regimen for rifampin-resistant tuberculosis | New England Journal of Medicine | | |
A longitudinal study of Ebola sequelae in Liberia | New England Journal of Medicine | | |
Ebola virus disease-related stigma among survivors declined in Liberia over an 18-month, post-outbreak period: An observational cohort study | PLoS Neglected Tropical Diseases | | |
Dose optimization of H56:IC31 vaccine for tuberculosis-endemic populations. a double-blind, placebo-controlled, dose-selection trial | American Journal of Respiratory and Critical Care Medicine | | |
Evaluation of the effects on the QT-interval of 4 artemisinin-based combination therapies with a correction-free and heart rate-free method | | | |
Single-dose tafenoquine to prevent relapse of Plasmodium vivax malaria | New England Journal of Medicine | | |
Tafenoquine versus primaquine to prevent relapse of Plasmodium vivax malaria | New England Journal of Medicine | | |
First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1 | | | |
Timing of rotavirus vaccine doses and severe rotavirus gastroenteritis among vaccinated infants in low- and middle-income countries | | | Rotavirus gastroenteritis |
A randomized trial of a new triple drug treatment for lymphatic filariasis | New England Journal of Medicine | | |
A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience | Contemporary Clinical Trials Communications | | |
Early Life Interventions for Childhood Growth and Development in Tanzania (ELICIT): a protocol for a randomised factorial, double-blind, placebo-controlled trial of azithromycin, nitazoxanide and nicotinamide | | | |
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19) | | | |
Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination | New England Journal of Medicine | | |
Utilizing nurses to staff an Ebola vaccine clinical trial in Sierra Leone during the Ebola outbreak | Journal of Infectious Diseases | | |
The Sierra Leone Trial to Introduce a Vaccine Against Ebola: An evaluation of rVSV∆G-ZEBOV-GP vaccine tolerability and safety during the West Africa Ebola outbreak | Journal of Infectious Diseases | | |
Rapid establishment of a cold chain capacity of –60°C or colder for the STRIVE Ebola vaccine trial during the Ebola outbreak in Sierra Leone | Journal of Infectious Diseases | | |
Participant retention in a randomized clinical trial in an outbreak setting: Lessons from the Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE) | Journal of Infectious Diseases | | |
Operationalizing international regulatory standards in a limited-resource setting during an epidemic: The Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE) experience | Journal of Infectious Diseases | | |
Monitoring serious adverse events in the Sierra Leone Trial to Introduce a Vaccine Against Ebola | Journal of Infectious Diseases | | |
Lessons learned in clinical trial communication during an Ebola outbreak: The implementation of STRIVE | Journal of Infectious Diseases | | |
Implementing a multisite clinical trial in the midst of an Ebola outbreak: Lessons learned from the Sierra Leone Trial to Introduce a Vaccine Against Ebola | Journal of Infectious Diseases | | |
Health conditions in an adult population in Sierra Leone: Data reported from the Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE) | Journal of Infectious Diseases | | |
Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial | | | |
Clinical surveillance and evaluation of suspected Ebola cases in a vaccine trial during an Ebola epidemic: The Sierra Leone Trial to Introduce a Vaccine Against Ebola | Journal of Infectious Diseases | | |
Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay | Journal of Virological Methods | | |
Timing and predictors of severe rotavirus gastroenteritis among unvaccinated infants in low- and middle-income countries | Epidemiology and Infection | | Rotavirus gastroenteritis |
Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial | | | |
Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial | The Lancet Respiratory Medicine | | |
Safety and immunogenicity of newborn MVA85A vaccination and selective, delayed Bacille Calmette-Guerin for infants of human immunodeficiency virus-infected mothers: a phase 2 randomized, controlled trial | Clinical Infectious Diseases | | |
Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study | Journal of Intensive Care | | |
Advancing global health through development and clinical trials partnerships: a randomized, placebo-controlled, double-blind assessment of safety, tolerability, and immunogenicity of PfSPZ vaccine for malaria in healthy Equatoguinean men | American Journal of Tropical Medicine and Hygiene | | |
Use of a novel portable three-dimensional imaging system to measure limb volume and circumference in patients with filarial lymphedema | American Journal of Tropical Medicine and Hygiene | | |
Phase 2 placebo-controlled trial of two vaccines to prevent Ebola in Liberia | New England Journal of Medicine | | |
Cerebrospinal fluid examination in survivors of Ebola virus disease | | | |
Durable response rate as an endpoint in cancer immunotherapy: insights from oncolytic virus clinical trials | Journal for the Immunotherapy of Cancer | | |
Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic | | | |
Conventional wisdom versus actual outcomes: challenges in the conduct of an Ebola vaccine trial in Liberia during the International Public Health Emergency | American Journal of Tropical Medicine and Hygiene | | |
Abrogation of red blood cell G6PD enzyme activity through Heat treatment: development of survey material for the UK NEQAS G6PD scheme | International Journal of Laboratory Hemotology | | |
Safety and immunogenicity of the recombinant Mycobacterium bovis BCG vaccine VPM1002 in HIV-unexposed newborn infants in South Africa | Clinical and Vaccine Immunology | | |
Establishment of a research pharmacy to support Ebola clinical research in Liberia | Science and Practice Advances in Pharmacy Practice | | |
Causes and outcomes of sepsis in Southeast Asia: A multinational multicentre cross-sectional study | | | |
Assessment and optimization of the GeneXpert diagnostic platform for detection of Ebola virus RNA in seminal fluid | Journal of Infectious Diseases | | |
Estimation of the in vivo MIC of cipargamin in uncomplicated Plasmodium falciparum malaria | Antimicrobial Agents and Chemotherapy | | |
First-in-human evaluation of the safety and immunogenicity of an intranasally administered replication-competent Sendai virus-vectored HIV type 1 Gag vaccine: induction of potent T-cell or antibody responses in prime-boost regimens | Journal of Infectious Diseases | | |
H1:IC31 vaccination is safe and induces long-lived TNF-α+IL-2+CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: A randomized trial | | | |
Heterogeneity of rotavirus vaccine efficacy among infants in developing countries | Pediatric Infectious Disease Journal | | Rotavirus gastroenteritis |
Beating the odds: successful establishment of a phase II/III clinical research trial in resource-poor Liberia during the largest-ever Ebola outbreak | Contemporary Clinical Trials Communications | | |
Efficacy and safety of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in patients with stage IIIB/C and IVM1a melanoma: subanalysis of the phase III OPTiM trial | | | |
A randomized, controlled trial of ZMapp for Ebola virus infection | New England Journal of Medicine | | |
Antimalarial activity of KAF156 in falciparum and vivax malaria | New England Journal of Medicine | | |
Ebola surveillance — Guinea, Liberia, and Sierra Leone | Morbidity and Mortality Weekly Report (MMWR) | | |
Ebola virus persistence in semen of male survivors | Clinical Infectious Diseases | | |
HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4(+) T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial | | | |
Assessing clinical research capacity in Vietnam: A framework for strengthening capability for clinical trials in developing countries | | | |
Fostering collaboration on post-Ebola clinical research in Liberia | | | |
Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam | Journal of Virus Eradication | | |
Assessment of the safety and immunogenicity of 2 novel vaccine platforms for HIV-1 prevention: a randomized trial | Annals of Internal Medicine | | |
Implementation of an Ebola virus disease vaccine clinical trial during the Ebola epidemic in Liberia: Design, procedures, and challenges | | | |
Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial | Lancet Infectious Diseases | | |
Factors associated with HIV RNA viral loads in ART-naïve patients: implications for treatment as prevention in concentrated epidemics | Journal of Virus Eradication | | |
Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial | Lancet Infectious Diseases | | |
Population pharmacokinetics of pyronaridine in pediatric malaria patients | Antimicrobial Agents and Chemotherapy | | |
Evaluation of Xpert® MTB/RIF assay in induced sputum and gastric lavage samples from young children with suspected tuberculosis from the MVA85A TB vaccine trial | | | |
Talimogene laherparepvec improves durable response rate in patients with advanced melanoma | Journal Of Clinical Oncology | | |
TH17-mediated protection against pneumococcal carriage by a whole-cell vaccine is dependent on toll-like receptor 2 and surface lipoproteins | Clinical and Vaccine Immunology | | |
The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial | | | |
A phase I double blind, placebo-controlled, randomized study of the safety and immunogenicity of an adjuvanted HIV-1 Gag-Pol-Nef fusion protein and adenovirus 35 Gag-RT-Int-Nef vaccine in healthy HIV-uninfected African adults | | | |
Multiple factors affect immunogenicity of DNA plasmid HIV vaccines in human clinical trials | | | |
Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial | The Lancet Respiratory Medicine | | |
Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial | | | |
Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A | | | |
The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses | | | |
Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response | | | |
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study | | | |
Helicase-primase inhibitor pritelivir for HSV-2 infection | New England Journal of Medicine | | |
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients | Journal of Infectious Diseases | | |
Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai health workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks | Journal of Antimicrobial Chemotherapy | | |
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial | | | |
Clinical validation of a point-of-care multiplexed in vitro immunoassay using monoclonal antibodies (the MSD Influenza Test) in four hospitals in Vietnam | Journal of Clinical Microbiology | | |
Malnutrition levels among vaccinated and unvaccinated children between 2 and 3 years of age following enrollment in a randomized clinical trial with the pentavalent rotavirus vaccine (PRV) in Bangladesh | | | Rotavirus gastroenteritis |
A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis–infected adults | American Journal of Respiratory and Critical Care Medicine | | |
The utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer–the ASCOLT study: study protocol for a randomized controlled trial | | | |
A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204) | | | |
Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants | Journal of Infectious Diseases | | |
Immunogenicity and safety of an investigational fully liquid hexavalent combination vaccine versus licensed combination vaccines at 6, 10, and 14 weeks of age in healthy South African infants | Pediatric Infectious Disease Journal | | |
Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial | | | Rotavirus gastroenteritis |
Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial | | | Rotavirus gastroenteritis |
Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial | | | |
The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults | American Journal of Respiratory and Critical Care Medicine | | |
Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells | European Journal of Immunology | | |
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa | Journal of Infectious Diseases | | |
